Compounds useful as inhibitors of atr kinase

Details Compounds useful as inhibitors of atr kinase Compounds useful as inhibitors of atr kinase

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4965 (2006.01) A61P 35/00 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2743134

The present disclosure relates to pyrazine compounds of formula (I) wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

La présente invention concerne des composés de pyrazine de la formule (I) dans laquelle L, n, R1 et R2 sont tels que décrits dans la spécification. Ces composés sont utiles comme inhibiteurs de la protéine kinase ATR. Linvention concerne également des compositions de qualité pharmaceutique qui comportent les composés de la description ; des méthodes de traitement de diverses maladies, divers troubles et états à laide desdits composés ; des procédés de préparation desdits composés ; des produits intermédiaires pour la préparation desdits composés, et des méthodes dutilisation des composés dans des applications in vitro, telles que létude des kinases dans des phénomènes biologiques et pathologiques ; létude de voies de transduction des signaux intracellulaires à médiation par de telles kinases, et lévaluation comparative de nouveaux inhibiteurs de la kinase.

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