Compounds useful as protein kinases inhibitors

Details Compounds useful as protein kinases inhibitors Compounds useful as protein kinases inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/551 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2695753

Compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of PLK1 protein kinases. These compounds have the formula I, as defined herein or pharmaceutically acceptable salts thereof. These compounds, and pharmaceutically acceptable salts thereof, are useful for treating or preventing a variety of diseases, disorders or conditions, including, but not limited to, an autoimmune, inflammatory, proliferative, or hyperproliferative disease, a neurodegenerative disease, or an immunologically-mediated disease. Formula I wherein R1is (formula); R6 is C1-4 aliphatic or C3-6 cycloaliphatic, and is optionally substituted with 1 or 2 halogen atoms; X is O and R2 is - CH3; or X is NR5 and, R2 and R5, together with the atoms to which they are attached, form a 1,2,4-triazole; each of R3 and R4 is independently H, methyl, or ethyl; or R3 and R4, together with the atoms to which they are attached, form a cyclopropyl ring; and n is 0 or 1.

Cette invention se rapporte à des composés utilisés comme inhibiteurs de protéines kinases. L'invention concerne par ailleurs des compositions pharmaceutiquement acceptables comprenant lesdits composés et des procédés d'utilisation des compositions dans le traitement de différentes maladies, différentes affections ou différents troubles.

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