Compounds useful as reversible inhibitors of cysteine proteases

Details Compounds useful as reversible inhibitors of cysteine proteases Compounds useful as reversible inhibitors of cysteine proteases

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/353 (2006.01) C07D 307/32 (2006.01)

Patent

CA 2463770

Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R2, R3, R4, R6, R8 and Y are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.

La présente invention concerne des composés inhibiteurs réversibles des cathepsines S, K, F, L et B, représentés par les formules générales (Ia, Ib). Dans ces formules, R¿2?, R¿3?, R¿4?, R¿6?, R¿8? et Y sont tels que décrits dans les spécifications. Ces composés conviennent pour le traitement de maladies auto-immunes et d'autres maladies. L'invention concerne également des procédés permettant l'élaboration de tels composés.

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