C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/17 (2006.01) A61K 31/497 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2573063
Substituted urea compounds useful in the treatment of diseases and C1 - 3alkyleneOR3 conditions related to DNA damage or lesions in DNA replication are disclosed formula (I), wherein X1 is null , - O- , - S - , - CH2- , or -N ( R1 ) - ; X2 is - O- , . - ~>.- , or -N (R1) - ,- . . Y xs 0 or S ; or =y represents two hydrogen atoms attached to a common carbon atom ,- W is selected from the group consisting of heteroaryl , aryl , heterocycloalkyl , cycloalkyl , and C1-6alkyl substi tuted with a heteroaryl. or aryl group ; R6 is -C.ident.C-R7 or heteroaryl ; R8 , R9 , and R10 , independently, are selected from the group consisting of halo , optionally substituted C1-6alkyl , C2-6alkenyl , C2-6alkynyl , OCP3 , CF3 , NO2 , CN, NC, N (R3) 2 , OR3 , CO2R3 , C ( O ) N (R3 ) 2 , C (O) R3 , N (R1 )COR3 , N (R1) C (O) OR3 , N (R8 ) C (O) OR3 , N (R1) C ( O) C1 -3alkyleneC (O) R3 , N ( R1) C (O) C1 - 3alkyleneC (O) OR3 , N (R1) C (O) C1 - 3alkyleneOR3 , N (R1) C (O) C1 - 3alkyleneNHC ( O) OR3 , N (R1) C (O) C1-3alkyleneSO2.NR3 , C1- 3alkyleneOR3 , and SR3 ; Methods of making the compounds , and their use as therapeutic agents , for example , in treating cancer and other diseases characterized by def ects in DNA repli cation , chromosome segregation , or cell division also are disclosed .
L'invention concerne des composés d'urée à substitution, utiles dans le traitement de maladies et d'états pathologiques associés à des dommages à l'ADN ou des lésions de l'ADN lors de la réplication de l'ADN. Cette invention concerne également des procédés pour produire lesdits composés et leur utilisation comme agents thérapeutiques, par exemple, dans le traitement du cancer ou d'autres maladies caractérisées par des défauts apparaissant lors de la réplication de l'ADN, la ségrégation des chromosomes ou la division cellulaire.
Cook Adam Wade
Gaudino John Joseph
Gowling Lafleur Henderson Llp
Icos Corporation
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