Compounds useful for inhibiting chk1

Details Compounds useful for inhibiting chk1 Compounds useful for inhibiting chk1

C - Chemistry, Metallurgy

07

D

C07D 241/20 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2577880

Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

L'invention concerne des composés d'urée substitués par aryle et hétéroaryle, utiles dans le traitement de maladies et états liés à un dommage à l'ADN ou à des lésions survenant lors de la réplication de l'ADN. L'invention concerne des méthodes de production desdits composés et leur utilisation comme agents thérapeutiques, par exemple, pour traiter le cancer ou d'autres maladies caractérisées par des défauts dans la réplication de l'ADN, la ségrégation des chromosomes ou la division cellulaire.

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