Compounds useful for inhibition of farnesyl protein transferase

Details Compounds useful for inhibition of farnesyl protein transferase Compounds useful for inhibition of farnesyl protein transferase

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2264511

Novel tricyclic compounds of Formula (1.0) are disclosed. Compounds of Formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R1, R3 and R4 are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.

L'invention concerne de nouveaux composés de formule (1.0), représentés par des composés de formules (1.4) ou (1.5), dans lesquelles R?1¿, R?3¿ et R?4¿ sont choisis indépendamment parmi les halogènes. L'invention concerne également des méthodes permettant d'inhiber la farnésyl-protéine transférase et la croissance des cellules anormales, notamment des cellules tumorales.

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