Compounds useful for the inhibition of aldh

Details Compounds useful for the inhibition of aldh Compounds useful for the inhibition of aldh

A - Human Necessities

61

K

A61K 31/352 (2006.01) C07D 311/34 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 417/12 (2006.01) C07H 17/07 (2006.01) C12Q 1/32 (2006.01)

Patent

CA 2491089

The present invention provides novel antidipsotropic compounds. The invention further provides methods of inhibiting ALDH-2 using the compounds described herein. Methods for modulating alcohol consumption, alcohol dependence and/or alcohol abuse by administering the compounds of the invention to an individual are also provided. The present invention further provides a rationale for designing additional novel antidipsotropic compounds.

La présente invention concerne de nouveaux composés antidipsotropiques et des procédés d'inhibition de ALDH-2 à l'aide de ces composés. L'invention concerne également des procédés de modulation de la consommation d'alcool, de la dépendance d'alcool et/ou de l'abus d'alcool par l'administration desdits composés à un individu. La présente invention concerne également un exposé désignant de nouveaux composés antidipsotropiques.

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