A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/02 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2287910
In accordance with the present invention, it has discovered that histone deacetylase associates with hormone receptor complexes and contributes to the repression thereof. It has further been discovered that exposure of a repressed system to histone deacetylase inhibitors relieves this repression. Thus, histone deacetylase inhibitors have been found to be useful for the activation of genes responsive to hormone receptors. In accordance with another aspect of the invention, formulations useful for modulation of hormone- mediated processes have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above- described processes.
L'invention concerne la découverte selon laquelle l'histone désacétylase s'associe à des complexes de récepteurs hormonaux et contribue à réprimer ceux-ci. Il a en outre été découvert que l'exposition d'un système réprimé à des inhibiteurs d'histone désacétylase permet de diminuer cette répression. Par conséquent, des inhibiteurs d'histone désacétylase sont utiles pour activer des gènes sensibles à des récepteurs hormonaux. Selon un autre aspect de l'invention, des formulations utiles pour la modulation de processus dépendant d'hormones ont été développés. De plus, des techniques ont été développées pour permettre d'identifier des composés utiles en vue de moduler les processus mentionnés.
Evans Ronald M.
Nagy Laszlo
Gowling Lafleur Henderson Llp
The Salk Institute For Biological Studies
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