Compounds useful in the therapy of alzheimer`s disease and...

C - Chemistry – Metallurgy – 07 – C

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C07C 49/743 (2006.01) A61P 25/28 (2006.01) C07C 49/733 (2006.01) C07C 403/16 (2006.01)

Patent

CA 2527354

Floroglucino salts, in particular salts of tetrahydro-and octahydro- hyperforin or adhyperforin derivates and of colupon with acetylcholinesterase- inhibiting alkaloids and methods for the preparation thereof. Said salts are useful for the treatment of depression and Alzheimer~s disease can be administered as conventional pharmaceutical formulations or as controlled- release transdermal preparations.

La présente invention concerne, d'une part des sels fluorogluciniques avec des alcaloïdes inhibiteurs des acétylcholinestérases, et d'autre part des procédés pour leur élaboration. Ces sels, qui conviennent au traitement de la dépression et de la maladie d'Alzheimer peuvent s'administrer sous forme de formulations pharmaceutiques conventionnelles ou de préparations transdermiques à libération contrôlée.

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