A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/407 (2006.01) A61K 31/43 (2006.01) A61K 31/431 (2006.01) A61P 31/04 (2006.01) C07D 477/20 (2006.01)
Patent
CA 2465854
This invention relates to a method of inhibiting growth of Bacillus anthracis, Bacillus cereus and/or Bacillus thuringiensis bacterial strains in a mammal comprising administration to a patient in need thereof a therapeutically effective amount of a carbapenem compound. In particular, this invention relates to a method of inhibiting growth of Bacillus anthracis, Bacillus cereusand/or Bacillus thuringiensis bacterial strains in a mammal using compounds having the structural formula (I) or a pharmaceutically acceptable salt, enantiomer, diastereomer or in vivo hydrolysable ester or mixture thereof. This invention further relates to the use of carbapenem compounds of formula I in the treatment of anthrax and other conditions which are related to an anthrax infection.
L'invention concerne un procédé d'inhibition de la croissance de souches des bactéries <i>Bacillus anthracis</i>, <i>Bacillus cereus</i> et/ou de <i>Bacillus thuringiensis</i> chez un mammifère consistant à administrer, à un patient la nécessitant, une quantité, efficace sur le plan thérapeutique, d'un composé carbapénème. Elle concerne, en particulier, un procédé d'inhibition de la croissance de souches des bactéries <i>Bacillus anthracis, Bacillus</i> <i>cereus </i> et/ou <i>Bacillus thuringiensis</i> chez un mammifère au moyen de composés de formule structurale (I) ou d'un de leurs sel, énantiomère, diastéréoisomère ou ester, hydrolysable in vivo, ou des combinaisons de ces produits, acceptables sur le plan pharmaceutique. Elle concerne aussi l'utilisation de composés carbapénème de formule (I) dans le traitement de l'anthrax et d'autres troubles associés à une infection par l'anthrax.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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