Compounds useful in the treatment of hiv

Details Compounds useful in the treatment of hiv Compounds useful in the treatment of hiv

A - Human Necessities

61

K

A61K 31/513 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2594229

There is provided inter alia use of 2',3'-dideoxy-3'-hydroxymethylcytosine or a prodrug or salt thereof in the manufacture of a medicament for the treatment of HIV infection wherein the reverse transcriptase of the HIV bears at least one mutation that allows an obligate chain terminating nucleoside- or nucleotide phosphate to be excised from the nascent DNA strand by ATP- or pyrophosphate-mediated excision.

L'invention porte, entre autre, sur l'utilisation de 2',3'-didésoxy-3'-hydroxyméthylcytosine ou d'un promédicament ou d'un sel de celui-ci dans la fabrication d'un médicament destiné à traiter une infection par le VIH dans laquelle la transcriptase l'inverse du VIH porte au moins une mutation qui permet d'exciser un phosphate de nucléoside ou nucléotide à terminaison de chaîne obligatoire du brin d'ADN à l'état naissant par excision induite par ATP ou pyrophosphate.

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