Compounds which are selective antagonists of the human nk3...

Details Compounds which are selective antagonists of the human nk3... Compounds which are selective antagonists of the human nk3...

C - Chemistry, Metallurgy

07

D

C07D 211/36 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 211/18 (2006.01) C07D 211/52 (2006.01) C07D 211/58 (2006.01) C07D 211/70 (2006.01) C07D 211/96 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 491/107 (2006.01)

Patent

CA 2145000

A compound of formula: (see formula I) in which: - Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a ( C1-C4) alkoxy; - R1 represents a methyl group; - R11 represents hydrogen; - or R1 and R11 together represent a -(CH2)3- group; - R2 represents a hydroxyl; a (C1-C7)alkoxy; a (C1-C7)acyloxy; a cyano; an -NR6R7 group; an -NR3COR4 group; an -NR3COOR8 group; an -NR3SO2R9 group; an -NR3CONR10R12 group; a (C1-C7)acyl group: a (C1- C7)alkoxycarbonyl; a -CONR10R12 group: a -CH2OH group; a (C1-C7)alkoxymethyl; a (C1-C7)acyloxymethyl; a (C1- C7)alkylaminocarbonyloxymethyl; a -CH2NR13R14 group; a -CH2NR3COR4 group; a -CH2NR3COOR8 group; a -CH2NR3SO2R9 group; a -CH2NR3CONR10R12 group; or R2 constitutes a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; - or Ar and R2, together with the carbon atom to which they are attached, constitute a group of formula: (see formula II) Application: NK3 antagonists

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