Compounds which can be retained in brain

Details Compounds which can be retained in brain Compounds which can be retained in brain

C - Chemistry, Metallurgy

07

C

C07C 323/41 (2006.01) A61K 47/06 (2006.01) A61K 47/48 (2006.01) C07C 327/30 (2006.01) C07D 207/16 (2006.01) C07D 209/20 (2006.01) C07D 213/56 (2006.01) C07D 233/64 (2006.01) C07D 239/42 (2006.01) C07D 295/13 (2006.01) C07D 295/145 (2006.01) C07D 307/54 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2120248

2120248 9403424 PCTABS00030 A group of novel compounds which can pass through the blood-brain barrier (BBB) with a drug carried thereon and reside in the brain to release the drug and a group of known compounds having the above characteristics. More specifically, a compound represented by general formula (Ia) and a salt thereof, wherein R1 represents hydroxy, carboxy, amino which may be substituted by C1-C6 alkyl, or C1-C6 alkyl which may be substituted by a 5- to 7-membered saturated heterocyclic group, R2 represents hydrogen or C1-C6 alkyl, R3 represents hydrogen or C1-C6 alkyl which may be hydroxylated, R4 represents hydrogen or C1-C6 alkyl, R5 represents amino acid residue, or -S-R6 or -CO-R6 (wherein R6 represents C1-C14 alkyl which may be substituted by a 5- to 7-membered saturated heterocyclic group, C1-C14 alkyl, C2-C6 alkenyl, aryl or a 5- to 7-membered saturated ring group), or a group represented by general formula (IVa), wherein R1, R2, R3 and R4 are each as defined above, and symbol .......... represents either a single or a double bond, provided that at least one of R1, R3 and R5 represents hydroxy, carboxy or amino.

Affiliated with

Also associated with

Rating

Compounds which can be retained in brain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds which can be retained in brain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds which can be retained in brain will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1612405