C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/26 (2006.01) A61K 31/4184 (2006.01) A61P 25/00 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2624504
Compounds which have activity at M1 receptor and their uses in medicine Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3- 6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1- 6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
Composés exerçant une activité au niveau du récepteur M1, et leurs utilisations en médecine. On décrit des composés de formule (I), y compris leurs sels et solvates. R4 est fluoro, R5 peut être hydrogène, halogène, cyano alkyle C1-6, alkyle C1-6 substitué par un ou plusieurs atomes de fluor, alcoxy C1-6 et alcoxy C1-6 substitué par un ou plusieurs atomes de fluor et R6 peut être halogène, cyano, alkyle C1-6 et alkyle C1-6substitué par un ou plusieursatomes de fluor,cycloalkyle C3-6, cycloalkyle C3-6 substitué par un ou plusieurs atomes de fluor, alcoxy C1-6, alcoxy C1-6 substitué par un ou plusieurs atomes de fluor, et Q est hydrogène ou alkyle C1-6. Ces composés sont censés être utiles en thérapie, par exemple pour le traitement de troubles psychotiques et de déficience cognitive.
Budzik Brian
Cooper David Gwyn
Forbes Ian Thomson
Garzya Vincenzo
Jin Jian
Glaxo Group Limited
Gowling Lafleur Henderson Llp
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