C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/78 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61P 25/28 (2006.01) C07C 311/08 (2006.01) C07C 311/29 (2006.01) C07D 207/09 (2006.01) C07D 209/14 (2006.01) C07D 211/26 (2006.01) C07D 213/40 (2006.01) C07D 213/61 (2006.01) C07D 213/65 (2006.01) C07D 213/74 (2006.01) C07D 215/12 (2006.01) C07D 241/12 (2006.01)
Patent
CA 2604291
The present invention provides novel beta-secretase inhibitors of the general formula (I), where the variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the claims, a method for their use in treating Alzheimer's disease, and methods for their use in reducing memapsin 2 catalytic activity.
La présente invention concerne de nouveaux inhibiteurs de la bêta-secrétase de formule générale (I), dans laquelle les variables A1, A2, L1, L2, L3, R1, R2, R3, R4, R5, R6 et R7 sont telles que définies dans les revendications, leur méthode d'utilisation dans le traitement de la maladie d'Alzheimer, ainsi que leurs méthodes d'utilisation pour réduire l'activité catalytique de la mémapsine 2.
Ankala Sudha
Bilcer Geoffrey
Devasamudram Thippeswamy
Ghosh Arun K.
Kumaragurubaran Nagaswamy
Comentis Inc.
Goudreau Gage Dubuc
Oklahoma Medical Research Foundation
Purdue Research Foundation
The Board Of Trustees Of The University Of Illinois
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