Compounds which inhibit leukocyte adhesion mediated by vla-4

Details Compounds which inhibit leukocyte adhesion mediated by vla-4 Compounds which inhibit leukocyte adhesion mediated by vla-4

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) C07D 207/48 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07K 5/065 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2359114

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Cette invention concerne des composés se liant à VLA-4. Certains de ces composés se caractérisent également par une adhésion leucocytaire, en particulier par une adhésion leucocytaire provoquée par VLA-4. Ces composés conviennent pour le traitement de maladies inflammatoires chez des mammifères, l'homme notamment, telles qu'asthme, maladie d'Alzheimer, athérosclérose, syndrome démentiel du SIDA, diabète, maladie intestinale inflammatoire, polyarthrite rhumatoïde, transplantations tissulaires, métastases tumorales et ischémie myocardique. Ces composés peuvent également être administrés pour le traitement de maladies inflammatoires du cerveau telles que la sclérose en plaques.

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