Compounds which inhibit leukocyte adhesion mediated by vla-4

Details Compounds which inhibit leukocyte adhesion mediated by vla-4 Compounds which inhibit leukocyte adhesion mediated by vla-4

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) A61K 38/05 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2290746

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

L'invention concerne des composés liant VLA-4. Certains de ces composés inhibent également l'adhésion leucocytaire, en particulier l'adhésion leucocytaire à médiation par VLA-4. De tels composés sont utiles pour le traitement de maladies inflammatoires telles que l'asthme, la maladie d'Alzheimer, l'athérosclérose, la démence liée au sida, le diabète, les affections intestinales inflammatoires, la polyarthrite rhumatoïde, les greffes tissulaires, les métastases tumorales et l'ischémie du myocarde chez les mammifères, notamment chez l'homme. Ces composés peuvent également être administrés dans le traitement de maladies cérébrales inflammatoires telles que la sclérose en plaques.

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