Compounds which inhibit the release of inflammatory cytokines

Details Compounds which inhibit the release of inflammatory cytokines Compounds which inhibit the release of inflammatory cytokines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61P 29/00 (2006.01) C07D 491/20 (2006.01) C07D 495/20 (2006.01)

Patent

CA 2461072

The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula (I): wherein R comprises ethers or amines; R1 is:a) substituted or unsubstituted aryl; orb) substituted or unsubstituted heteroaryl; R2a and R2b units are each independently hydrogen, ethers, amines, amides, carboxylates, or said units can form a double bond, a carbonyl, or R2a and R2b can be taken together to form a substituted or unsubstituted ring comprising from 4 to 8 atoms, said ring selected from the group consisting of: i) carbocyclic; ii) heterocyclic; iii) aryl; iv) heteroaryl; v) bicyclic; and vi) heterobicyclic

La présente invention concerne des composés représentés par la formule (I) qui sont capables d'empêcher la libération extracellulaire des cytokines inflammatoires, l'invention concernant lesdits composés, y compris toutes leurs formes énantiomères et diastéréoisomères ainsi que leurs sels pharmaceutiquement acceptables. Dans la formule, R comprend des éthers ou des amines; R1 représente: a) aryle substitué ou non substitué; ou b) hétéroaryle substitué ou non substitué; les unités R2a et R2b représentent chacune indépendamment hydrogène, des éthers, des amines, des amides, des carboxylates, ou bien lesdites unités peuvent former une liaison double, un carbonyle, ou R2a et R2b peuvent être pris ensemble pour former un anneau substitué ou non substitué comprenant de 4 à 8 atomes, ledit anneau étant sélectionné dans le groupe formé par: i) carbocyclique; ii) hétérocyclique; iii) aryle; iv) hétéroaryle; v) bicyclique; et vi) hétérobicyclique. Formule (I) Formule (I)

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