Compounds which modulate the cb2 receptor

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 215/30 (2006.01) A61K 31/135 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) C07C 217/58 (2006.01) C07C 317/32 (2006.01) C07D 213/64 (2006.01) C07D 213/74 (2006.01) C07D 215/12 (2006.01)

Patent

CA 2643863

Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein R1, R2, R3, X and Ar have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

La présente invention concerne des composés qui se lient au récepteur CB2, et sont des agonistes, des antagonistes ou des agonistes inverses de celui-ci. Les composés sont représentés par la formule générale (I), R1, R2, R3, X et Ar ayant les significations données dans la description. L'invention concerne également la préparation et l'utilisation de ces composés. Les composés sont de précieux modulateurs du récepteur CB2, et sont utiles pour le traitement d'une inflammation. Les composés qui sont des agonistes sont, de plus, utiles pour le traitement de la douleur.

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