Compounds with 5-ht1a activity useful for treating disorders...

Details Compounds with 5-ht1a activity useful for treating disorders... Compounds with 5-ht1a activity useful for treating disorders...

A - Human Necessities

61

K

A61K 31/137 (2006.01) A61K 31/36 (2006.01) A61K 31/404 (2006.01) A61K 31/4045 (2006.01) A61K 31/428 (2006.01) A61K 31/438 (2006.01) A61K 31/4433 (2006.01) A61K 31/4439 (2006.01) A61K 31/445 (2006.01) A61K 31/451 (2006.01) A61K 31/4545 (2006.01) A61K 31/4745 (2006.01) A61K 31/496 (2006.01) A61K 31/553 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2400639

Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed. The disorder is selected from the group consisting of: AMD; RP and other forms of heredodegenerative retinal disease; retinal detachment and tears; macular pucker; ischemia affecting the outer retina; diabetic retinopathy; damage associated with laser therapy (grid, focal, and panretinal) including photodynamic therapy (PDT); trauma; surgical (retinal translocation, subretinal surgery, or vitrectomy) or light-induced iatrogenic retinopathy; and preservation of retinal transplants. The compounds is selected from the group consisting of: tandospirone, urapidil, ziprasidone, repinotan hydrochloride, xaliproden hydrochloride (SR- 57746A), buspirone, flesinoxan, EMD-68843, DU-127090, gepirone, alnespirone, PNU-95666, AP-521, flibanserin, MKC-242, lesopitron, sarizotan hydrochloride, E-5842, SUN-N4057, Org-13011, Org-12966 and 8-OH-DPAT.

L'invention concerne des compositions et des méthodes destinées au traitement des affections de la rétine externe à l'aide de composés ayant une activité agoniste sur le récepteur 5-HT¿1A?.

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