Compounds with a sequence of three radicals, the central one...

Details Compounds with a sequence of three radicals, the central one... Compounds with a sequence of three radicals, the central one...

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070169

Compounds of general formula A-B-C in which: A is a monovalent radical of a laevorotatory ring molecule; B is a bivalent radical of a laevorotatory .alpha.-aminoacid: and C is a monovalent radical of a laevorotatory aromatic molecule. The compounds show an anti-hypertensive, analgesic, immuno-modulating and antiinflammatory activity, they are resistant to enzyme hydrolysis and they can be used for the preparation of drugs for oral administration.

Composés de formule générale A-B-C dans laquelle: A représente un radical monovalent d'une molécule cyclique lévogyre; B représente un radical bivalent d'un acide aminé alpha lévogyre; C représente un radical monovalent d'une molécule aromatique lévogyre. Les composés présentent une efficacité anti-hypertensive, analgésique, immuno-modulante et anti-inflammatoire, ils sont résistants à l'hydrolyse enazymatique et peuvent s'utiliser dans la préparation de médicaments administrés par voie orale.

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