Compounds with activity at retinoic acid receptors

Details Compounds with activity at retinoic acid receptors Compounds with activity at retinoic acid receptors

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/192 (2006.01) A61K 31/235 (2006.01) A61K 31/34 (2006.01) A61K 31/426 (2006.01) A61K 31/4402 (2006.01)

Patent

CA 2613458

Disclosed herein are novel compounds with activity at RAR.beta. 2 receptors. Further disclosed are the use of such compounds for treatment of or to alleviate symptoms of cancer, neurological disorders such as memory deficits and schizophrenia, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases, inflammatory disorders such as psoriasis and rheumatoid arthritis, eye disorders and depression.

L'invention se rapporte à de nouveaux composés présentant une activité au niveau des récepteurs de RARß 2. Cette invention concerne en outre l'utilisation de ces composés pour traiter le cancer, des troubles neurologiques tels que des déficiences de la mémoire et la schizophrénie, des troubles nerodégénératifs tels que la maladie de Parkinson et la maladie d'Alzheimer, des troubles inflammatoires tels que le psoriasis et l'arthrite rhumatoïde, des troubles oculaires, et la dépression, ou pour atténuer les symptômes de ces différentes affections.

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