Compounds with anti-cancer activity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 207/452 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2684037

Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

L'invention concerne de nouveaux azole-diones substitués qui tuent des cellules, empêchent la prolifération de cellules, inhibent la croissance cellulaire, éliminent le point de contrôle du cycle cellulaire en G2 et/ou entraînent l'adaptation à l'arrêt du cycle cellulaire en G2. L'invention concerne également des méthodes de production et d'utilisation des composés. Elle concerne l'utilisation d'azole-diones substitués pour tuer sélectivement ou supprimer des cellules cancéreuses sans traitement anti-cancéreux additionnel. L'invention concerne en outre l'utilisation d'azole-diones substitués éliminant le point de contrôle du cycle cellulaire en G2 pour sensibiliser sélectivement les cellules cancéreuses par rapport aux réactifs qui dégradent l'ADN, aux traitements et/ou autres types de réactifs anti-cancéreux.

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