C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/28 (2006.01) A61K 31/16 (2006.01) A61K 31/21 (2006.01) A61K 31/47 (2006.01) C07C 259/10 (2006.01) C07C 271/08 (2006.01) C07C 275/16 (2006.01) C07C 275/42 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 307/79 (2006.01) C07D 333/54 (2006.01)
Patent
CA 2254066
Compounds of formula (I), wherein R' is hydrogen or alkyl; A is adamantyl or a mono-, bi- or tricyclic residue optionally unsaturated, a heterocyclic residue and/or substituted by hydroxy, alkanoyloxy, amino, aminoalkyl, halogen, alkyl, trialkylammoniumalkyl; (a) is a chain of 1 to 5 carbon atoms optionally containing a double bond or a NR'; R is hydrogen or phenyl; X is 0 or NR' or is absent; r and m are independently 0, 1 or 2; B is phenylene or cyclohexylene; Y is hydroxy or aminoalkyl optionally interrupted by an O; have anti-inflammatory and immunosuppressive activities.
Composés de formule (I) dans laquelle R' représente hydrogène ou alkyle; A représente amadantyle ou un reste mono, bi ou tricyclique éventuellement insaturé, un reste hétérocyclique et/ou substitué par hydroxy, alcanoyloxy, amino, aminoalkyle, halogène, alkyle, trialkylammoniumalkyle, (a) est une chaîne de 1 à 5 atomes de carbone contenant éventuellement une liaison double ou un NR'; R représente hydrogène ou phényle; X représente O ou NR' ou est absent; r et m valent indépendamment 0, 1, ou 2; B représente phénylène ou cyclohexylène; Y représente hydroxy ou aminoalkyle éventuellement interrompu par un O. Lesdits composés ont des activités anti-inflammatoire et immunosuppressive.
Bertolini Giorgio
Biffi Mauro
Leoni Flavio
Mascagni Paolo
Mizrahi Jacques
Italfarmaco S.p.a.
Kirby Eades Gale Baker
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