Compounds with anti-ks and anti-hiv activity

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/59 (2006.01) A61K 31/00 (2006.01) A61K 38/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2299054

The present invention relates to a compound having anti-KS and anti-HIV pharmaceutical activity which comprises an HCG-like inhibitory protein and fragments or derivatives thereof, said protein and fragments thereof are isolated from a biologically active fraction of APL-HCG, wherein said protein has a molecular weight of about 3,500 or of about 13,000 Dalton, and wherein said protein and fragments thereof are adsorbed polypropylene plastic supports. A pharmaceutical composition for the prevention and/or treatment of Kaposi's sarcoma (KS) and HIV which comprises a therapeutically effective amount of at least one compound of the present invention in association with a pharmaceutically acceptable carrier. A method for the prevention, treatment and/or reduction of Kaposi's sarcoma and HIV expression in AIDS patients, which consists in administering the composition to the patient.

Cette invention se rapporte à un composé ayant une activité pharmaceutique anti-SK et anti-VIH, qui contient une protéine inhibitrice de type HCG et des fragments ou dérivés de celle-ci, cette protéine et ses fragments étant isolés d'une fraction biologiquement active de APL-HCG, cette protéine ayant une masse moléculaire d'environ 3500 ou d'environ 13000 Daltons, et cette protéine et ses fragments étant adsorbés sur des supports plastiques en polypropylène. Cette invention concerne également une composition pharmaceutique servant à prévenir et/ou traiter le sarcome de Kaposi (SK) et le VIH, cette composition contenant au moins un composé de cette invention, en quantité efficace sur le plan thérapeutique, associé à un excipient acceptable sur le plan pharmaceutique, ainsi qu'un procédé servant à prévenir, traiter et/ou réduire l'expression du sarcome de Kaposi et du VIH chez des patients atteints du SIDA, ce procédé consistant à administrer à ces patients la composition en question.

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