C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/06 (2006.01) A61K 31/075 (2006.01) A61K 31/343 (2006.01) A61P 25/16 (2006.01) A61P 25/30 (2006.01) C07C 43/188 (2006.01) C07D 309/08 (2006.01)
Patent
CA 2426604
Featured compounds have high monoamine transport affinity and are characterized by one of the following two general formulas set out above. The compounds bind selectively or non-selectively to monoamine transporters. The compounds are useful to treat various medical indications including, without limitation, attention deficit hyperactivity disorder (ADHD), Parkinson's disease, cocaine addiction, smoking cessation, weight reduction, obsessive- compulsive disorder, various forms of depression, traumatic brain injury, stroke, and narcolepsy.
La présente invention concerne des composés qui ont une forte affinité pour un transporteur de monoamine et qui sont représentés par une des deux formules suivantes (I) et (II). Les composés se lient sélectivement ou non sélectivement aux transporteurs de monoamine. Ces composés sont utiles pour traiter diverses pathologies telles que, entre autres, le trouble d'hyperactivité avec déficit de l'attention (THADA), la maladie de Parkinson, la cocaïnomanie, le sevrage du tabac, la perte de poids, les troubles obsessionnels-compulsifs, diverses formes de dépression, les lésions cérébrales traumatiques, l'apoplexie et la narcolepsie.
Blundell Paul
Madras Bertha K.
Meltzer Peter C.
Wang Pinglang
Dimock Stratton Llp
Organix Inc.
President And Fellows Of Harvard College
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