C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/251
C07D 401/12 (2006.01) C07D 213/74 (2006.01) C07D 215/38 (2006.01) C07D 215/42 (2006.01) C07D 217/22 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 235/12 (2006.01) C07D 235/30 (2006.01) C07D 239/42 (2006.01) C07D 239/94 (2006.01) C07D 263/58 (2006.01) C07D 277/42 (2006.01) C07D 277/82 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1260468
A B S T R A C T Compounds of the formula (I) : Image (I) or pharmaceutically acceptable salts thereof, wherein : R1 and R2 are independently C1-4alkyl; or R1 and R2 together with the nitrogen atom to which they are joined represent a pyrrolidino, piperidino or hexahydro- azepino ring; Y is straight-chain or branched-chain C1-4alkyl; n is 2 to 5; m is 0 or 1; when m is l, Z is inter alia an optionally substituted pyridine, pyrimidine, oxazole, thiazole, imidazole, benzoxazole benzthiazole or N-alkylbenzimidazole ring; when m is O, Z is an optionally substituted imidazole, pyrazole or benzimidazole ring. The compounds are histamine H2-receptor antagonists and are relatively lipophilic and can penetrate the blood-brain barrier and are useful in treating diseases mediated via histamine H2-receptors. Processes for their preparation, pharmaceutical compositions and methods of use are described.
493967
Brown Thomas H.
Mitchell Robert C.
Smith Ian R.
Young Rodney C.
Gowling Lafleur Henderson Llp
Smith Kline & French Laboratories Limited
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