Compounds with kv4 ion channel activity

Details Compounds with kv4 ion channel activity Compounds with kv4 ion channel activity

C - Chemistry, Metallurgy

07

D

C07D 307/85 (2006.01) A61K 31/343 (2006.01) A61K 31/404 (2006.01) A61P 9/00 (2006.01) C07D 209/42 (2006.01) C07D 215/48 (2006.01) C07D 307/82 (2006.01) C07D 333/70 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2587664

The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, Formula (I), (II), (III), (IV), wherein X1, X2, Y, Z, W, R1, R8 , R9, R10, L, A, z, and n have the meaning defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.

L'invention concerne des composés inter-réagissant avec des canaux ioniques. En particulier, l'invention concerne des composés ayant la formule développée (I), (II), (III) ou (IV), des stéréoisomères, des tautomères, des racémiques, des promédicaments, des métabolites de ces composés, ou un sel et/ou un solvat pharmaceutiquement acceptable desdits composés, formules dans lesquelles X1, X2, Y, Z, W, R1, R8, R9, R10, L, A, z, et n ont les significations spécifiées dans la revendication 1. L'invention concerne également des procédés de préparation desdits composés, des compositions pharmaceutiques comprenant lesdits composés et l'utilisation de ces composés dans des procédés de traitement du corps humain ou animal.

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