A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/404 (2006.01) A61K 31/44 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2713288
Disclosed herein are drug compounds that have MDR-inverse activity and thus are effective against multidrug-re-sistant cells. Exemplary compounds disclosed herein have the following structure: (I). Examples of the disclosed compounds have been found to have, inter alia, efficacy in directly treating multidrug resistant cells, rendering multidrug resistant cells susceptible to other chemotherapeutics and in some instances reversing multidrug resistance.
La présente invention concerne des composés médicamenteux qui ont une activité MDR inverse et qui sont donc efficaces contre les cellules multirésistantes. Des exemples de composés décrits ici ont la structure suivante : (I). Des exemples des composés décrits se sont avérés avoir, entre autre, une efficacité dans le traitement direct de cellules multirésistantes, rendant les cellules multirésistantes sensibles à dautres produits chimiothérapeutiques et dans certains cas dans linversion de la multirésistance.
Fales Henry M.
Gottesman Michael M.
Hall Matthew D.
Hellawell Jennifer L.
Ludwig Joseph A.
Goudreau Gage Dubuc
Hungarian Academy O. F. Sciences Institute Of Enzymology Biological Research Center
The Government Of The United States Of America As Represented By
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