C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4166 (2006.01) A61K 31/4418 (2006.01) A61K 31/501 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) C07D 213/85 (2006.01) C07D 215/22 (2006.01) C07D 215/227 (2006.01) C07D 233/70 (2006.01) C07D 235/00 (2006.01) C07D 237/04 (2006.01) C07D 239/00 (2006.01)
Patent
CA 2506741
This invention provides compounds that possess inhibitory activity against .beta.-~adrenergic receptors and phosphodiesterase PDE, including phosphodiesterase 3 (PDE3 ). This invention further provides pharmaceutical compositions comprising such ~compounds; methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine; and methods of preparing pharmaceutical compositions and compounds that possess inhibitory activity against .szlig.-adrenergic receptors and PDE.
L'invention concerne des composés qui présentent une activité d'inhibition des récepteurs .beta.-adrénergiques et de la phosphodiestérase PDE, y compris la phosphodiestérase 3 (PDE3). L'invention concerne de plus des compositions pharmaceutiques contenant de tels composés ; des méthodes utilisant ces composés pour traiter une maladie cardiovasculaire, un accident vasculaire cérébral, l'épilepsie, un trouble ophtalmique ou la migraine ; et des procédés de préparation de compositions pharmaceutiques et de composés présentant une activité d'inhibition des récepteurs .beta.-adrénergiques et de la PDE.
Hamilton Gregory S.
Leighton Harry Jefferson
Artesian Therapeutics Inc.
Mccarthy Tetrault Llp
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