C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2428552
The present invention relates to peptides which are highly biologically and pharmacologically active as therapeutic drug for the treatment of diseases related to hypertension, especially in medical interventions involving dilatation and remodelling of arterial blood vessels, either in the pulmonary or in the systemic circulation. The peptides which can be used according to the invention for the treatment of said diseases comprises at least one specific highly conservative amino acid residue sequence which seem to play an important role in connection with pulmonary and arteriolar hypertension events. It could be shown that the known naturally occurring peptides "vasoactive intestinal peptide (VIP)"and pituitary adenylate cyclaseactivating polypeptide (PACAP)", having these specific sequences are potent drugs which can be successfully used for treatment of primary pulmonary hypertension (PPH), secondary pulmonary hypertension (SPH), and hypertension of the systemic circulation. Furthermore, the present invention discloses pharmaceutical compositions useful for treatment of PPH, SPH, and hypertension of the systemic circulation within said methods.
L'invention concerne des peptides extrêmement actifs sur le plan biologique et pharmacologique et servant de médicament thérapeutique afin de traiter des maladies apparentée à l'hypertension, en particulier, dans des interventions médicales consistant à dilater et à remodeler des vaisseaux sanguins artériels, soit dans la circulation pulmonaire, soit dans la circulation systémique. Ces peptides, pouvant être mis en application selon l'invention afin de traiter lesdites maladies, comprennent au moins une séquence résiduelle d'acides aminés spécifiques extrêmement conservative qui semble jouer un rôle important par rapport à des événements d'hypertension pulmonaire et artériolaire. On pourrait démontrer que ces peptides naturels connus, "peptide intestinal vasoactif (VIP)" et "polypeptide d'activation d'adénylate cyclase pituitaire (PACAP)" présentant ces séquences spécifiques, constituent des médicaments puissants qu'on peut utiliser positivement afin de traiter l'hypertension pulmonaire primaire (PPH), l'hypertension pulmonaire secondaire (SPH) et l'hypertension de la circulation systémique. L'invention concerne, de plus, des compositions pharmaceutiques utiles pour traiter PPH, SPH, ainsi que l'hypertension de la circulation systémique au moyen desdits procédés.
Mondobiotech Ag
Mondobiotech Sa
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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