Compressed microparticles for dry injection

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/20 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2398533

The invention relates to a pharmaceutical implant for controllably releasing a drug in a subject and methods for manufacturing and administering the implant. The implant is made of associated microparticles of a drug dispersed in a biodegradable polymer. The microparticles are sufficiently associated so that the implant maintains a predetermined shape but are not fused together so as to form a single monolithic structure. The drug can be controllably released in a subject by administration of the pharmaceutical implant without the need of a suspending fluid.

L'invention concerne un implant pharmaceutique permettant la libération lente d'un médicament chez un sujet ainsi que des méthodes de fabrication et d'administration de cet implant. Cet implant est constitué de microparticules d'un médicament associées, lesquelles sont dispersées dans un polymère biodégradable. Ces microparticules sont suffisamment associées pour que l'implant conserve une forme prédéterminée mais ne sont pas fusionnées de manière à former une seule structure monolithique. Ce médicament peut être libéré lentement chez un sujet par administration de l'implant pharmaceutique sans avoir à utiliser un fluide en suspension.

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