Compressed pharmaceutical compositions comprising peg and...

A - Human Necessities – 61 – K

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Details

A61K 31/765 (2006.01) A61K 9/20 (2006.01) A61K 33/14 (2006.01) A61P 1/10 (2006.01)

Patent

CA 2561649

The invention provides a compressed pharmaceutical composition comprising polyethylene glycol of molecular weight from 2000 to 4500, wherein the polyethylene glycol makes up from 80 to 99.5% by weight of the composition, one or more electrolytes for the treatment of constipation, faecal impaction, faecal retention, intestinal gas and cramping, or flatulence; or for orthostatic lavage, colon evacuation or colon cleansing. It has been found, surprisingly, that a compressed pharmaceutical composition comprising PEG for example a solid tablet, is significantly more palatable than previously proposed compositions and is effective when administered. The compressed pharmaceutical composition of the invention comprising polyethylene glycol has been found to have a more agreeable taste and a more agreeable mouthfeel than previously proposed liquid or dry powder or granular compositions.

L'invention concerne une composition pharmaceutique comprimée comprenant un polyéthylène glycol ayant un poids moléculaire entre 2000 et 4500, le polyéthylène glycol représentant entre 80 et 99,5 % en poids de la composition, un ou plusieurs électrolytes destinés au traitement de la constipation, de la surcharge fécale, de la rétention fécale, des gaz intestinaux, des crampes ou du gonflement; ou pour un lavage orthostatique, l'évacuation du colon ou le nettoyage du colon. On a découvert étonnamment qu'une composition pharmaceutique comprimée comprenant, par exemple, PEG, tel qu'un comprimé solide, est sensiblement plus sapide que les compositions proposées jusqu'à présent, et qu'elle est plus efficace lorsqu'elle est administrée. La composition pharmaceutique comprimée de la présente invention comprenant du polyéthylène glycol a un goût et une sensation dans la bouche plus agréables que les compositions granulaires, liquides ou sous forme de poudre sèche proposées jusqu'à présent.

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