A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/216 (2006.01)
Patent
CA 2626234
One of the objects of the present invention is directed to a process of preparing a pharmaceutical formulation of a drug of low aqueous solubility, comprising (A) fixing the drug in a strong matrix comprising at least one at least partially amorphous sugar to obtain a sugar-drug matrix; and (B) milling the sugar-drug matrix to obtain a milled sugar-drug matrix as the pharmaceutical formulation. The invention also provides the pharmaceutical formulation prepared by the process.
L'invention concerne entre autres un procédé de préparation d'une formulation pharmaceutique d'un médicament de faible solubilité dans l'eau, consistant à (A) fixer le médicament dans une matrice résistante comprenant au moins un sucre au moins partiellement amorphe pour obtenir une matrice sucre-médicament ; et (B) broyer la matrice sucre-médicament pour obtenir une matrice sucre-médicament broyée en tant que formulation pharmaceutique. L'invention concerne également la formulation pharmaceutique préparée par le procédé.
Kopel Mira
Zalit Ilan
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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