Compressed tablets

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A23L 1/00 (2006.01) A23L 1/22 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2717494

The invention provides a compressed tablet including a volatile active agent, preferably menthol, within a spray-dried granule further comprising a starch carrier and, optionally, a polyol granulating agent. The compressed tablet can be a two layer tablet comprising an effervescent layer and a non-effervescent layer with the spray-dried granule incorporated into the effervescent layer. The tablets herein are useful for providing decongestant benefits. The present invention further relates to the use of starch for increasing the rate of release of menthol from a compressed tablet. The use of starch as a carrier for the volatile active agent has been found to not only improve its rate of release from the tablet compared to other carriers, such as gum arabic, or compared to not using a carrier at all, but also to impart improved smoothness to the tablet when sucked.

L'invention porte sur un comprimé compressé comprenant un agent actif volatil, de préférence le menthol, à l'intérieur de granulés séchés par pulvérisation comprenant en outre un support d'amidon et, facultativement, un agent de granulation de type polyol. Le comprimé compressé peut être un comprimé à deux couches comprenant une couche effervescente et une couche non effervescente, les granulés séchés par pulvérisation étant incorporés dans la couche effervescente. Les comprimés selon l'invention sont utiles pour offrir des avantages décongestionnants. La présente invention porte en outre sur l'utilisation d'amidon pour augmenter la vitesse de libération du menthol à partir d'un comprimé compressé. Il a été observé que l'utilisation d'amidon en tant que support pour l'agent actif volatil non seulement améliore sa vitesse de libération à partir du comprimé, par comparaison avec d'autres supports tels que la gomme arabique, ou par comparaison avec la non utilisation dun support, mais encore confère une texture lisse améliorée au comprimé lorsqu'il est avalé.

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