A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/52 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61K 9/56 (2006.01)
Patent
CA 2479057
The aim of the invention is to provide a multi(micro)particulate compressed tablet which comprises a non-mechanically-deformable active principle core (crystal, granule) and which allows the prolonged in vivo release of said active principle, without the release profile being modified by the compression (microparticles not specifically formulated for the compression). Said aim is achieved with the inventive compressed tablet comprising reservoir-type microcapsules with prolonged release of the active principle. According to the invention, each of said microcapsules is formed by a non-deformable core comprising the active principle and covered by at least one coating film which controls the prolonged in vivo release of the active principle. Moreover, each microcapsule has a particle size distribution of between 50 and 1,000 ?m and comprises at least one outer overcoating envelope which is based on at least one deformable organic component having a melting temperature of between 40 ·C and 120 ·C (polyethylene glycol). The invention also relates to the overcoated microcapsules which are resistant to compression.
Le but de l'invention est de proposer un comprimé multi(micro)particulaire, comprenant un c ur de principe actif PA mécaniquement non déformable (cristal, granule), permettant la libération prolongée in vivo de ce PA, sans modification du profil de libération par la compression (microparticules non spécifiquement formulées pour la compression). Ce but est atteint par le comprimé selon l'invention, ô base de microcapsules réservoir, ô libération prolongée du PA, et :" formées chacune par un c ur non déformable comprenant du PA et recouvert par au moins une pellicule d'enrobage contrôlant la libération prolongée in vivo du PA, " possédant une granulométrie comprise entre 50 et 1 000 ~m " et comprennent au moins une enveloppe externe de surenrobage ô base d'au moins un constituant organique déformable présentant une température de fusion comprise entre 40~C et 120~C (polyéthylèneglycol).Les microcapsules surenrobées résistantes ô la compression sont également visées en tant que telles par l'invention.
Autant Pierre
Jorda Rafael
Flamel Technologies
Robic
LandOfFree
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