Compressible starches as binders for tablets or capsules

Details Compressible starches as binders for tablets or capsules Compressible starches as binders for tablets or capsules

C - Chemistry, Metallurgy

08

B

167/153, 167/168

C08B 30/12 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1249519

COMPRESSIBLE STARCHES AS BINDERS FOR TABLETS OR CAPSULES ABSTRACT OF THE DISCLOSURE A compressible starch, useful as a binder for tablets prepared by direct compression or dry granulation or as a binder-diluent for capsules, is prepared by treating a cold-water-insoluble, granular starch (e.g., corn or waxy corn starch) with an acid, and/or alpha-amylase enzyme at a temperature below the starch's gelatiniza- tion temperature. The treated starch is characterized by altered, weakened granules with a less dense interior and disrupted surface. The compressible starch when admixed with a wet granulation binder (e.g., pregelatinized starch) is useful as a binder for tablets pre- pared by wet granulation as well as direct compression or dry granu- lation or as a binder-diluent for capsules.

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