Computer-assisted formulation of culture media

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/04 (2006.01) C12N 5/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G06F 17/50 (2006.01)

Patent

CA 2378528

Methods, apparatus and computer program products are provided for identifying a component of culture medium based on the parameters (e.g., physical, chemical, biological and/or topological characteristics) of compounds from within a compound library. In preferred embodiments, the compound library is a peptide library. Also provided are methods of selecting a compound library from a larger compound space based on whole molecule (i.e., global) parameters of the compounds. Preferably, this method is practiced in conjunction with a method of identifying a component of a culture medium. Further provided are methods of predicting a biological activity of a peptide based on at least one whole molecule parameter of the peptide. This method finds use in methods of drug discovery, identifying components of culture medium, and identifying and/or designing peptides with particular pharmacological or therapeutic activities.

L'invention concerne des procédés, un appareil et un programme informatique destinés à identifier un composé d'un milieu de culture se basant sur les paramètres (notamment les caractéristiques physique, chimique, biologique et/ou topologique) de composés d'une bibliothèque de composants. Dans des modes de réalisation préférés, la bibliothèque de composants est une banque de peptides. L'invention concerne également des procédés de sélection d'une bibliothèque de composants provenant d'un espace de composants plus large basé sur les paramètres moléculaires entiers (à savoir, globaux) des composants. Ce procédé est, de préférence, utilisé conjointement à un procédé d'identification d'un composé d'un milieu de culture. L'invention porte, en outre, sur des procédés permettant de prévoir une activité biologique d'un peptide basé sur au moins un paramètre moléculaire entier du peptide. Ce procédé est utilisé dans la découverte de médicaments, dans l'identification de composés d'un milieu de culture, et dans l'identification et/ou la conception de peptides possédant des activités pharmacologiques et thérapeutiques particulières.

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