Computer-directed detection of paraproteins

Details Computer-directed detection of paraproteins Computer-directed detection of paraproteins

G - Physics

01

N

G01N 27/447 (2006.01)

Patent

CA 2297092

Identification and quantification of paraproteins in a sample is achieved by Fourier analysis of mobility-based electropherograms obtained from capillary electrophoresis. The use of a computer algorithm to analyze capillary electrophoresis data, provides the clinician with methods of detecting levels of paraproteins in serum as low as 0.05 g/dL. Additionally, an individual paraprotein can be located on an electropherogram and used to monitor its increased or decreased production in an individual.

On effectue l'identification et la quantification de paraprotéines dans un spécimen par analyse de Fourier d'électrophorégrammes basés sur la mobilité et obtenus par électrophorèse capillaire. L'utilisation d'un algorithme informatique afin d'analyser des données d'électrophorèse capillaire fournit au clinicien des procédés permettant de détecter des niveaux de paraprotéines dans du sérum, qui sont extrêmement bas, de l'ordre de 0,05 g/dL. On peut localiser, de plus, une paraprotéine individuelle dans l'électrophorégramme et la mettre en application afin de contrôler l'augmentation ou la diminution de sa production chez un individu.

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