Concentrated liquid valdecoxib composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/08 (2006.01) A61K 31/415 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2505106

The present invention provides a pharmaceutical composition comprising a liquid carrier, valdecoxib and cyclodextrin derivative in an amount of at least about 5%, w/v, of the composition. The valdecoxib is in solubilized form and, at room temperature, the ratio of valdecoxib concentration to cyclodextrin concentration is greater than is achievable in a substantially similar solution but which comprises less than 5%, w/v, of said cyclodextrin derivative.

L'invention concerne une composition pharmaceutique comprenant un support liquide, au moins environ 5 % en poids de la composition de dérivé de valdécoxibe et de cyclodextrine. Le valdécoxibe se présente sous forme soluble et, à température de laboratoire, le taux de concentration de valdécoxibe par rapport à la cyclodextrine est supérieur à celui réalisable dans une solution sensiblement similaire mais contenant moins de 5% en poids de dérivé de cyclodextrine.

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