Concentrated methotrexate solutions

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/519 (2006.01) A61K 9/00 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2659662

The invention relates to concentrated methotrexate solutions containing an active substance for the production of a parenterally administered medicament for the treatment of inflammatory autoimmune diseases. The methotrexate is added to a pharmaceutically compatible solvent, in a concentration of more than 25mg/ml. The invention also relates to a ready-made syringe, a carpule containing such a pharmaceutical solution formulation, and a pen injector comprising such a carpule and/or a ready-made syringe.

L'invention concerne des solutions de méthotrexate concentrées qui sont appropriées pour l'utilisation d'une substance active, en vue de produire un médicament à administrer par voie parentérale, destiné au traitement de maladies auto-immunes inflammatoires. Le méthotrexate est alors introduit dans un solvant pharmaceutiquement compatible, à une concentration supérieure à 25 mg/ml. L'invention concerne également une seringue prête à l'emploi, ainsi qu'une ampoule contenant une telle formulation de solution pharmaceutique, et un stylo-injecteur comprenant une telle ampoule et/ou une seringue prête à l'emploi.

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