Concentrated stabilized microbubble-type ultrasonic imaging...

Details Concentrated stabilized microbubble-type ultrasonic imaging... Concentrated stabilized microbubble-type ultrasonic imaging...

A - Human Necessities

61

K

167/46

A61K 49/00 (2006.01) A61B 8/00 (2006.01) A61K 9/50 (2006.01) A61K 49/22 (2006.01)

Patent

CA 1325590

ABSTRACT A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium contain- ing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas micro- bubbles encapsulated with water-insolubilized biocompatible ma- terial. The imaging agent is characterized by having a concen- tration of greater than 100 x 106 microspheres per milliliter, and a stability such that this concentration is maintained for over 4 weeks at a temperature of 20 to 25°C.

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