Concomitant pharmaceutical agents and use thereof

Details Concomitant pharmaceutical agents and use thereof Concomitant pharmaceutical agents and use thereof

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 31/133 (2006.01) A61K 31/155 (2006.01) A61K 31/427 (2006.01) A61K 31/64 (2006.01) A61K 38/22 (2006.01) A61K 38/28 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01) A61P 13/00 (2006.01) A61P 13/12 (2006.01) A61P 25/00 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2610361

A concomitant preparation for simultaneous or separate use comprising a combination of (a) 3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl) piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine, a salt of the compound and an organic or inorganic mono- or di-basic acid or a solvate of the compound or salt and (b) at least one active ingredient selected from the group consisting of an active ingredient of a pharmaceutical agent selected from (i) an anti-diabetic agent, (ii) a lipid lowering agent, (iii) anti- hypertensive agent, (iv) a therapeutic agent for a diabetic complication, (v) an anti-obesity agent, (vi) an anti-platelet agent and (vii) an anti- coagulant, a pharmaceutically acceptable salt of each of these agents and a solvate of each of the agents or the salt.

L~invention concerne une préparation concomitante pour un usage simultané ou séparé comprenant une combinaison de (a) la 3-[(2S,4S)-4-[4-(3-méthyl-1-phényl-1H-pyrazol-5-yl)-pipérazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine, un sel du composant et un mono ou diacide organique ou inorganique ou un produit de solvatation du composé ou du sel et (b) d~au moins une substance active choisie dans le groupe constitué par une substance active d'un agent pharmaceutique choisi parmi (i) un agent antidiabétique, (ii) un agent hypolipidémiant, (iii) un agent antihypertenseur, (iv) un agent thérapeutique pour une complication diabétique, (v) un agent antiobésité, (vi) un agent antiplaquettaire et (vii) un anticoagulant, un sel pharmaceutiquement acceptable de chacun de ces agents et un produit de solvatation de chacun des agents ou du sel.

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