Concurrent in-vivo immunoconjugate binding to multiple...

Details Concurrent in-vivo immunoconjugate binding to multiple... Concurrent in-vivo immunoconjugate binding to multiple...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61K 38/43 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2614782

The present invention provides an immunological preparation comprising not less than two types of conjugate molecules in admixture for concurrent specific binding to a spatially exposed region of vascular permeability factor (VPF) bound in-vivo to a tumor- associated blood vessel. Each conjugate molecule type comprises at least a binding portion of an antibody specific for an epitope present within a spatially exposed region of bound VPF; and an effector moiety covalently bound to the specific binding portion. The immunological preparation has wide uses and applications including analytical studies, in-vivo diagnostic testing, and in-vivo therapeutic treatments.

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