Condensed compounds, their production and use

Details Condensed compounds, their production and use Condensed compounds, their production and use

C - Chemistry, Metallurgy

07

D

C07D 491/048 (2006.01) A61K 31/395 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2200469

This invention provides new condensed furan compounds of formula (I) which exhibit excellent 2,3-oxidosqualene cyclase inhibition and high-density lipoprotein-cholesterol elevating activities. This invention also provides a therapeutic and prophylactic agent of formula (I') for hyperlipidemia, hypercholesterolemia and atherosclerosis.

On décrit des nouveaux composés furane condensés de la formule (I) possédant d'excellentes propriétés d'inhibition de la 2,3-oxydosqualène-cyclase ainsi que d'élévation du cholestérol à lipoprotéines de haute densité. On décrit également un agent de la formule (I') destiné à la thérapie et à la prophylaxie de l'hyperlipidémie, l'hypercholestérolémie et l'athérome.

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