C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/210, 260/239
C07D 519/00 (2006.01) A61K 31/55 (2006.01) C07D 413/14 (2006.01) C07D 487/10 (2006.01)
Patent
CA 2025005
Abstract Condensed diazepinones Condensed diazepinones of formula I Image (I) (wherein ] ? represents one of the divalent groups Image (s) (r) (u) (v) X represents a =CH- group or a nitrogen atom; R represents a lower alkyl group optionally substituted by a phenyl group itself optionally substituted by halogen, methyl or methoxy; R4 and R5 represent hydrogen, halogen or lower alkyl; R6 represents hydrogen, chlorine or methyl; R7 and R8 represent hydrogen or lower alkyl and R8 may also represent halogen; m, n, o and p each represents the number 1 or 2 with the proviso that the sum of m+n+o+p must be no greater than 6) and their isomers and salts are suitable for the treatment of cholinergically induced spasms and motility disorders in the gastrointestinal tract and in the region of the outward leading bile ducts, for the symptomatic treatment of cystitis and spasms in urelithiasis, for the treatment of relative incontinence, for the symptomatic treatment of bronchial asthma and bronchitis and for the treatment of ischaemic heart disease. The compounds have a high degree of selectivity.
de Jonge Adriaan
Doods Henri
Eberlein Wolfgang
Engel Wolfhard
Mayer Norbert
Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung
Fetherstonhaugh & Co.
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