Condensed heterocyclic compounds, their production and use

Details Condensed heterocyclic compounds, their production and use Condensed heterocyclic compounds, their production and use

C - Chemistry, Metallurgy

07

D

C07D 215/227 (2006.01) A61K 31/35 (2006.01) A61K 31/47 (2006.01) C07D 215/18 (2006.01) C07D 215/54 (2006.01) C07D 217/24 (2006.01) C07D 217/26 (2006.01) C07D 241/44 (2006.01) C07D 241/52 (2006.01) C07D 311/18 (2006.01) C07D 311/58 (2006.01) C07D 311/76 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 455/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2105518

Novel compound represented by the formula: Image wherein ring A may be substituted; ring B represents an optionally substituted benzene ring; either X or Y represents -NR1- (R1 represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted amino group), -O- or -S-, the other representing -CO-, -CS- or -C(R2)R2a- (R2 and R2a independently represent a hydrogen atom or an optionally substituted hydrocarbon group), or either X or Y represents -N=, the other representing =CR3- (R3 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group , an optionally substituted amino group, a substituted hydroxyl group or a mercapto group substituted by an optionally substituted hydrocarbon group); ~~~ ~~~~ represents a single or double bond; when ~~~~~~~~ is a single bond, Z represents -CR4- (R4 represents a hydrogen atom, hydroxyl group or an optionally substituted hydrocarbon group) or a nitrogen atom, or (ii) when ~~ ~~~~ is a double bond, Z represents a carbon atom; D represents a C1-3 alkylene group which may be substituted by an oxo group or a thioxo group, or D and Y, taken together, may form a 5- to 7- membered ring which may be substituted by an oxo group or a thioxo group; E represents -NR5- (R5 represents a hydrogen atom or an optionally substituted hydrocarbon group), -O- or -S(O)n- (n is 0,1 or 2), or R5 and Y, taken together, may form a 5- to 7- membered ring which may be substituted by an oxo group or a thioxo group; G represents a bond or a C1-3 alkylene group; Ar represents an optionally substituted aryl group or an optionally substituted heterocyclic group, provided that (1) when (i) -X-Y- represents - O-CO- or -CO-O-, (ii) D represents -CO- and (iii) E represents -NR5-, either (a) G represents a C1-3 alkylene group and Ar represents a substituted aryl group or a substituted heterocyclic group, or (b) G represents a bond and R5 represents an optionally substituted hydrocarbon group, and (2) when -X-Y- represents -NH-CO-, D represents -CO-, or a salt thereof having an excellent activity of inhibiting ACAT, lowering chlesterol in blood and inhibiting tachykinin recepter, or a salt thereof, their production and use.

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