C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/220, 167/231
C07D 487/04 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2032695
Abstract of the disclosure: The compounds of the formula, Image z-?- CONHCHCOOR1 CH2CH2COOR2 wherein the ring A is a pyrrole ring which may be hydrogenated; - B - is a divalent cyclic or chain group which may be substituted; one of Q1 and Q2 is N, with the other being N or CH; W is a halogen or hydrogen atom or a group bonded to the bonding line with a carbon, nitrogen, oxygen or sulfur atom, provided that W is not -NH2; X is an amino, hydroxyl or mercapto group; Y is a hydrogen atom or a hydroxyl or amino group; Z is a straight-chain divalent group having a number of atoms of 2 to 5 composed of carbon atoms which each may be substituted, or carbon atoms which each may be substituted and one hetero atom which may be substituted; -COOR1 and -COOR2 each is the same as or different from the other and represents a carboxyl group which may be esterified, or salts thereof are provided. The compounds are produced by reacting compounds of the formula, Image COOR3 wherein A, - B -, W, W, X, Y, Q1 and Q2 are the same as defined above, with compounds of the formula, Image wherein -COOR1 and -COOR2 are the same as defined above, and useful as anti-tumor agents.
Akimoto Hiroshi
Hitaka Takenori
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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