C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/218, 260/252
C07D 487/04 (2006.01) A61K 31/505 (2006.01) C07D 239/70 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2034292
Abstract of the disclosure: Novel compounds of the formula: Image wherein the ring A is a 5-membered ring, provided that, in the case where the ring A is a pyrrole or pyrroline ring, (i) the N atom in the ring has no active proton or (ii) the ring bonds to Z at the -position of the ring; B is a divalent cyclic or chain group which may be substituted; one of Q1 and Q2 is N, with the other being N or CH; Y is a hydrogen or halogen atom or a group which bonds to the bonding line with a carbon, nitrogen, oxygen or sulfur atom; X is an amino, hydroxyl or mercapto group; Z is a straight-chain divalent group having a number of atoms of 2 to 5 composed of carbon atoms which each may be substituted, or of carbon atoms which each may be substituted and one hetero atom which may be substituted; -COOR1 and -COOR2 each is the same as or different from the other and represents a carboxyl group which may be esterified or its salts are produced by reacting compounds of the formula, Image wherein A, B, Q1, Q2, X, Y, and Z are the same as defined above, with compounds of the formula, Image wherein -COOR1 and -COOR2 are the same as defined above. The compounds are useful as an antitumor agent.
Akimoto Hiroshi
Ootsu Koichiro
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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