Condensed heterocyclic system derivatives, preparation,...

C - Chemistry – Metallurgy – 07 – D

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C07D 311/68 (2006.01) A61K 31/35 (2006.01) C07D 335/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2321218

The invention concerns novel products of general formula (I), their preparation, pharmaceutical compositions containing them and the use thereof for preparing medicines. In general formula (I) R¿1? represents a -CO-CH(NH¿2?)-CH¿2?SH, or -CH¿2?-CH(NH¿2?)-CH¿2?SH, or -CHRi1Ri2 radical; R¿2? represents a hydrogen atom, an alkyl, aralkyl, aryl, alkylcarbonyl, aralkylcarbonyl, heterocycloalkyl radical; R¿3? represents a hydrogen atom or a halogen atom or an alkyl, aryl, aralkyl radical; R¿4? represents a -CHRi3Ri4 radical; R¿5? represents a hydrogen atom, or a -C(O)-Ri¿5? radical; R¿6? represents a hydrogen atom or an alkyl, aryl, aralkyl radical; R¿7?, R¿8? represent a hydrogen atom or an alkyl, aryl, aralkyl radical; X represents a hydrogen atom or a -S(O)¿1? radical.

Nouveaux produits de formule générale (I), leur préparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la préparation de médicaments. Dans la formule générale (I), R1 représente un radical -CO- CH(NH2)-CH2SH, ou -CH2-CH(NH2)-CH2SH, ou -CHRi1Ri2; R2 représente un atome d'hydrogène, un radical alkyle, aralkyle, aryle, alkylcarbonyle, aralkylcarbonyle, arylcarbonyle, hétérocyclalkyle; R3 représente un atome d'hydrogène ou un atome d'halogène ou un radical alkyle, aryle, aralkyle; R4 représente un radical -CHRi3Ri4; R5 représente un atome d'hydrogène, ou un radical -C(O)-Ri5; R6 représente un atome d'hydrogène ou un radical alkyle, aryle, aralkyle; R7, R8 représentent un atome d'hydrogène ou un radical alkyle, aryle, aralkyle; X représente un atome d'oxygène ou un radical -S(O)1.

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